Odomzo (sonidegib)

In stock
Odomzo (sonidegib)

Odomzo (sonidegib) is a medication for the treatment of locally advanced basal cell carcinoma (BCC) that cannot be treated with surgery or radiation therapy.

Oncology Skin Cancer
Marketing Authorisation Holder Sun Pharmaceutical Industries Europe B.V.
Mode of Action Hedgehog pathway inhibitor
Administration Oral
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia
Strength 200 milligram
Package 30 Capsules

What is Odomzo (sonidegib) for?

Odomzo (sonidegib) is indicated for the treatment of patients with basal cell carcinoma which is locally advanced and which cannot be treated either by surgery or by radiotherapy1,2,3. 

How does Odomzo (sonidegib) work?

The Hedgehog signalling pathway is a set of processes that control a number of cell activities including cell growth and correct development and differentiation. The active ingredient in Odomzo, sonidegib,  attaches to a protein that controls the Hedgehog signalling pathway. By attaching to this protein, sonidegib blocks the Hedgehog signalling pathway, thereby reducing the growth and spread of cancer cells1.

The most common side effects are muscle spasms, hair loss, taste disturbance, tiredness, nausea, vomiting, muscle and bone pain, belly ache, headache, diarrhoea, weight loss, loss of appetite, and itching. Women who are pregnant or breastfeeding must not take Odomzo1.

Is Odomzo (sonidegib) approved?

Odomzo (sonidegib) was approved for the treatment of adults with locally advanced basal cell carcinoma (BCC) that cannot be treated with surgery or radiation therapy by:

  • FDA (USA) on July 24, 20153
  • EMA (EU) on August 14, 20151
  • TGA (AUS) on December 19, 20162

How do I take Odomzo (sonidegib)?

The standard dosage is:

  • One 200 mg capsule once a day at least 1 hour before and 2 hours after a meal.
Complete information about Odomzo (sonidegib) dosage and administration can be found in the resources section.

Note: Consult your treating doctor for personalised dosing.

Are there any known adverse reactions of Odomzo (sonidegib)?

Common adverse reactions

The most common adverse reactions (incidence ≥10%) listed in the prescribing information include:

  • muscle spasms

  • alopecia

  • dysgeusia

  • fatigue

  • nausea

  • musculoskeletal pain

  • diarrhoea

  • decreased weight and decreased appetite

  • myalgia

  • abdominal pain

  • headache

  • pain

  • vomiting

  • pruritus (itching).

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include: 

  • musculoskeletal adverse reactions

Use in specific populations

As Odomzo (sonidegib) can be fatal for a fetus, pregnancy and breastfeeding is not advised during and for up to 20 months after the last dose.

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.

More Information
Working ingredient sonidegib
Shipping method Cold chain (temperature controlled)
Package 30
Therapeutic Area Oncology
Oncology Skin Cancer
Indication Locally advanced basal cell carcinoma (BCC)
Administration Oral
Mode of Action Hedgehog pathway inhibitor
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia
Marketing Authorisation Holder Sun Pharmaceutical Industries Europe B.V.

The approvals of Odomzo (sonidegib) for locally advanced BCC were based on one main study involving 230 patients with basal cell carcinoma which was either locally advanced or metastatic. Patients were started on two different doses of sonidegib: 200 or 800mg once a day. The response on metastatic BCC was less than 20%. However, the medicine resulted effective on patients with locally advanced BCC with a response rate of 56% (95% CI: 43.3, 68.3) on the 200 mg dose, with 5% complete responses, and 45% (95% CI: 43.3, 68.3)4 on the 800 mg dose1. On the 200 mg dosage, the time to tumour response was 4.0 months (95% CI: 3.8, 5.6) and the median duration of response was 26.1 months4.

1. Human Medicines: Odomzo (sonidegib) [PDF]
    EMA, cited May 2015

2. Summary of Product Characteristics [TGA]: Odomzo (sonidegib)
    TGA, Oct. 2017

3. Summary of Product Characteristics [FDA]: Odomzo (sonidegib) [PDF]
    Sun Pharmaceutical Industries, Sep. 2017

4. Summary of Product Characteristics [EMA]: Odomzo (sonidegib) [PDF]
    Sun Pharmaceutical Industries Europe B.V., Mar 2018

Shipping Type Cold Chain
Shipping method Cold chain (temperature controlled)
Dynamic Weight No
This content has been reviewed by our medical doctor Jan de Witt.

How can we help you?

We're ready to answer any question!

Our Support team is available between
9:00–18:00 Central European Time, Monday to Friday.


Don't speak English? We also speak
Afrikaans, Armenian, Bosnian, Bulgarian, Dutch, German, Italian, Lithuanian, Mandarin, Portuguese, Russian, Serbian, Slovenian, Spanish and Turkish


Speak a different language?
Send us a message and we’ll do our best to translate.


Our guarantee: We will reply to all messages within 2 hours during office hours.


If you want to reach us via phone or chat, please visit our contact page


The Social Medwork is registered with the Dutch Ministry of Health in The Hague as an independent intermediary, Registration number 6730 BEM
100% legal and regulated
Registered with the Dutch Ministry of Health as an independent intermediary.


Registration number 6730 BEM
Secured logistics globally
• Standard and express delivery (DHL or UPS)
• 24/7 track & trace delivery
• Temperature regulated shipping
Secure payments
All payments are handled securely and are SSL encrypted.
We accept:
Bank transfer & Credit card


Patient reviews

 Tomasz Maćkowiak

During the transaction process I was very well informed by the TheSocialMedwork team. They have put as much of their effort to offer best service to me. Moreover the medicine I have ordered was imported two weeks earlier then it was expected. I highly recommend The Social Med Work.

Patient reviews

 Emina Mušović

Thank you for the wonderful cooperation! It's very reserved of us to say we're pleased because you really resolved all our doubts. The medicine has now arrived and we hope it helps. We know we were difficult, with the million different questions but well... That's all behind us now. Strongly recommended! :)

Patient reviews

 Mohamed Rahmat

I am fully satisfied with your online support service. Happy to deal with you.. fast & very fast support.. did not have to wait even 5 minutes! THANK YOU MEDWORK

Questions our patients are asking

visit our support page
You always need a prescription from a doctor based in your country. Other documents, such as an import license from the Ministry of Health, may be needed and depend on your country’s regulations. Contact us and we will provide you with all of the information about the required documents needed for your country.
For prescription medicines you will always need a prescription from your treating doctor. This is to ensure that your treatment is monitored and led by a doctor who is responsible for administering the medicine to you. The prescription is the evidence that your doctor gives you their medical support.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised medicine couriers. If you want us to use a specific courier please inform us when you place your order.
Yes. TheSocialMedwork is registered with the Dutch Ministry of Health as an independent medicines intermediary (registration number 6730 BEM). We always follow your country’s laws and regulations and will discuss any legal requirements with you. We only ship medicines when our patients have a prescription from their treating doctor.
By using TheSocialMedwork you will receive genuine medicines in perfect condition, no matter where you live.
Yes, you are welcome to visit us. We are located in the city centre of Amsterdam at the Herengracht 480. Contact us to schedule the best time for your visit.


You can order and receive your
medicine in 5 simple steps


Talk to your doctor


Place order
and send


Pay for order


Check documents
for delivery


Receive your medicine

Totally awesome!
Keep up the great
work you’re doing!

Dee Penfold - December 3, 2016
On TheSocialMedwork Facebook

Need a medicine that’s not
approved in your country?

We help patients, physicians and pharmacists acquire the latest life-changing medicines. Not available in your country? No problem - as long as it's approved by a reputable medical authority somewhere, we can help! Contact us today and our experienced team of qualified pharmacists and industry professionals will help you.

learn more
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.