Calcort (deflazacort)

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Calcort (deflazacort)

How to buy Calcort (deflazacort): You can order Calcort (deflazacort) from TheSocialMedwork if the drug has not been approved or is not available in your country. We help patients and doctors get access to medicines at the lowest price worldwide. 

Neurology Duchenne Muscular Dystrophy
Marketing Authorisation Holder Merrell Dow/Henning
Mode of Action Glucocorticoid
Administration Oral
Regulatory agency approval Medicines & Healthcare products Regulatory Agency (MHRA), United Kingdom, The Federal Institute for Drugs and Medical Devices (BfArM), Germany
Strength 6 milligram

What is Calcort (deflazacort) for?

Calcort (deflazacort) is indicated for the treatment of patients with several conditions. including:

  • inflammation including asthma, arthritis, and allergies

  • skin, kidney, heart, digestive system, eyes or blood conditions

  • tumours

Calcort (deflazacort) can also be used to suppress the immune system in transplant operations.

Moreover, deflazacort has been frequently used for the treatment of Duchenne muscular dystrophy (DMD)5,6,7,8,12,13 and is referred to as the most commonly prescribed corticosteroid for DMD in Canada1.

How does Calcort (deflazacort) work?

Glucocorticoids are a class of corticosteroids which occur naturally in the body and help to maintain health and wellbeing. Boosting your body with extra corticosteroid is an effective way to treat various illnesses involving inflammation in the body. Deflazacort works by reducing this inflammation. It also stops reactions known as autoimmune reactions. These reactions occur when your immune system attacks the body itself causing damage2.

Is Calcort (deflazacort) approved?

Calcort is approved in several countries including:

  • MHRA approved (UK)
  • BfArM approved (DE)

Unlike most of our products, deflazacort isn’t a new medicine and is marketed under several different names across the world3,9. Among several other countries, it is approved under the name Calcort in the UK10 and Germany11.

How is Calcort (deflazacort) taken?

Complete information about Calcort (deflazacort) dosage and administration can be found in the resources section2.

Note: Consult your treating doctor for personalised dosing.

More Information
Working ingredient deflazacort
Shipping method Controlled room temperature (temperature controlled)
Therapeutic Area Neurology
Neurology Duchenne Muscular Dystrophy
Indication Several conditions involving inflammation in the body: Asthma; Arthritis; Allergies; Tumours; Immune system suppression; Skin, kidney, heart, digestive system, eyes or blood conditions; Duchenne muscular dystrophy (off-label)
Administration Oral
Mode of Action Glucocorticoid
Regulatory agency approval Medicines & Healthcare products Regulatory Agency (MHRA), United Kingdom, The Federal Institute for Drugs and Medical Devices (BfArM), Germany
Marketing Authorisation Holder Merrell Dow/Henning

Besides its many uses in the treatment of inflammations and autoimmune diseases2, the benefits of deflazacort on DMD emerged from several studies1,5,6,7,8,12,15. Corticosteroids are the standard therapy to delay DMD progression12 with some reports indicating less weight gain in patients using deflazacort than those using other corticosteroids, like prednisolone1,5,7,8,12,13,15.

In February 2017 deflazacort received FDA approval for the treatment of DMD under the name Emflaza, manufactured by Marathon Pharmaceuticals4,14. This approval was based on a study of 196 boys, ranging from 5 to 15 years old15. The study lasted 52 weeks and compared deflazacort at two different dosages (0.9 or 1.2 mg/ kg/ day) with prednisone (another corticosteroid commonly used to treat DMD) and placebo.

After 12 weeks of treatment, both deflazacort (at both dosages) and prednisone showed superior changes in average muscles strength scores: deflazacort produced a score of 0.15 with the dosage of 0.9 mg/ kg/ d (95% CI 0.01, 0.28)16 and a score of 0.26 with the of dosage 1.2 mg/ kg/ d (95% CI 0.12, 0.40); prednisone produced a score of 0.27 (95% CI 0.13—0.41); placebo produced a score of -0.1 (95 % CI -0.23, 0.03)15.

Moreover, both medications were better than placebo on several timed motor function tests (i.e., time to stand from supine, time to climb four stairs and time to walk or run 30 feet)15. From week 12 to week 52 the group treated with deflazacort with the dosage of 0.9 mg/ kg/ d showed better results in changes of average muscle strength score (0.17, 95% CI 0.03, 0.31) than the group treated with prednisone (-0.12, 95% CI -0.26, 0.03)15.

1. The Canadian experience with long term deflazacort treatment in Duchenne muscular dystrophy.
    Acta Myol. L.C. Mc Adam, et al., May 2012

2. Package leaflet: Calcort (deflazacort), [PDF]
    Sanofi S.p.a., December 2016

3. Deflazacort
    Wikipedia, cited March 2017

4. FDA News Release: FDA approves drug to treat Duchenne muscular dystrophy
    FDA, Feb 2017

5. Deflazacort. A review of its pharmacological properties and therapeutic efficacy
    H.M. Drugs.  A. Markham and H.M. Bryson, Aug 1995 

6. Long-term outcome of interdisciplinary management of patients with Duchenne muscular dystrophy     receiving daily glucocorticoid treatment
    J. of Pediatrics. B.L. Wong, et al., Mar 2017

7. Glucocorticoid corticosteroids for Duchenne muscular dystrophy
    Cochrane Database Syst. A.Y. Manzur, et al, January 2008

8.Deflazacort Improves Muscle Strength, Functional Outcomes in Duchenne Muscular Dystrophy
   Neurology Advisor. A. Ciccione, September 2016

9. Deflazacort
    cited March 2013

10. Calcort 6mg Tablets, eMC
      cited March 2017

11. DIMDI – Recherche-Einstieg – AMIS Öffentlicher Teil. Searched word: deflazacort.
      cited March 2017

12. Duchenne Muscular Dystrophy: From Diagnosis to Therapy. Molecules
      M.S. Falzarano, et al, Oct 2015

13. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and        psychosocial management
      The Lancet Neurology. K. Bushby, et al, Nov 2009

14. Marathon Pharmaceuticals News Release: FDA approves Emflaza (deflazacort) tablets and oral           suspension for the treatment of Duchenne muscular dystrophy in patients 5 years and older
      Feb 2017

15. Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy
      Neurology. R.C. Griggs, et al, Nov 2016

16. Summary of Product Characteristics [FDA]: Emflaza (deflazacort)
      Marathon Pharmaceuticals, Feb 2017

Shipping Type Cold Chain
Shipping method Controlled room temperature (temperature controlled)
This content has been reviewed by our medical doctor Jan de Witt.

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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.