Cometriq (cabozantinib)

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Cometriq (cabozantinib)

How to buy Cometriq (cabozantinib): You can order Cometriq (cabozantinib) from TheSocialMedwork if the drug has not been approved or is not available in your country. We help patients and doctors get access to medicines at the lowest price worldwide.

Oncology Thyroid Cancer
Marketing Authorisation Holder Ipsen Pharma
Mode of Action Kinase inhibitor (chemotherapy)
Administration Oral
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA

What is Cometriq (cabozantinib) for?

Cometriq (cabozantinib) is a cancer medicine indicated for the treatment of patients with progressive, metastatic medullary thyroid cancer (MTC)1,2.

How does Cometriq (cabozantinib) work?

The active substance in Cometriq, cabozantinib, is a tyrosine kinase inhibitor. It blocks the activity of enzymes known as tyrosine kinases. These enzymes can be found in certain receptors in cancer cells where they activate several processes including cell division and the growth of new blood vessels to supply the cancer. By blocking the activity of these receptors in cancer cells, the medicine reduces the growth and spread of the cancer1.

Is Cometriq (cabozantinib) approved?

Cometriq (cabozantinib) was approved for progressive, metastatic medullary thyroid cancer (MTC)1,2 by:

  • FDA (USA) on November 29, 20124
  • EMA (EU) on March 26, 20141

How is Cometriq (cabozantinib) taken?

The standard dosage is:

  • 140 mg orally, once daily

Patients should not eat for at least 2 hours before and at least 1 hour after taking it1,2.

Warning: Cabozantinib tablets should not be substituted with cabozantinib capsules.

It can be expected that a majority of patients will require one or more dose adjustments (reduction and/or interruption) due to toxicity. When dose reduction is necessary, it is recommended to reduce to 100 mg daily, taken as one 80 mg capsule and one 20 mg capsule, and then to 60 mg daily, taken as three 20 mg capsules2,3.

Complete information about Cometriq (cabozantinib) dosage and administration can be found in the resources section.  

Note: Consult your treating doctor for personalised dosing.

Are there any known side-effects of Cometriq (cabozantinib)?

There are some warnings and precautions associated with Cometriq (cabozantinib). Two of these are the occurrence of gastrointestinal perforations and fistulas, and haemorrhage. See the prescribing information for a complete list3,2.

More Information
Working ingredient cabozantinib
Shipping method Controlled room temperature (temperature controlled)
Therapeutic Area Oncology
Oncology Thyroid Cancer
Indication Progressive, metastatic medullary thyroid cancer (MTC)
Administration Oral
Mode of Action Kinase inhibitor (chemotherapy)
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA
Marketing Authorisation Holder Ipsen Pharma
HS Code 29334990
CAS Number 849217-68-1

The approvals were based on a study involving 330 adults with medullary thyroid cancer that could not be treated with surgery, where the cancer was extensive or had spread to other parts of the body.

The main measure of effectiveness was progression-free survival (how long the patients lived before their disease got worse):

  • in patients given Cometriq (cabozantinib) this was 11.2 months, compared with 4.0 months in those given placebo1,4

  • Results also showed that 27% of patients treated with Cometriq (cabozantinib) had reductions in tumour size lasting an average of 14.7 months (95% CI: 11.1, 19.3), while patients who received a placebo saw no reductions.

  • Treatment with Cometriq (cabozantinib) did not extend patients’ lives4

1. Human Medicines: Cometriq (cabozantinib), EMA
    cited Jan 2017

2. Summary of Product Characteristics [FDA]: [PDF] Cometriq (cabozantinib), Exelixis Inc.,
    Nov 2012

3. Summary of Product Characteristics [EMA]: [PDF] Cometriq (cabozantinib)
    Ipsen Pharma, Mar 2014

4. FDA approves Cometriq to treat rare type of thyroid cancer
    FDA, Nov 2012

Shipping Type Standard
Shipping method Controlled room temperature (temperature controlled)
This content has been reviewed by our medical doctor Jan de Witt.

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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.