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How to buy Ongentys (opicapone): You can order Ongentys (opicapone) from TheSocialMedwork if the drug has not been approved or is not available in your country. We help patients and doctors get access to medicines at the lowest price worldwide.
Ongentys (opicapone) is indicated for the treatment of adult patients with Parkinson disease. It is used as an add-on to levodopa/DOPA decarboxylase inhibitors (DDCI) (other medicines for Parkinson’s disease) in patients who are having fluctuations in the control of their condition1.
How does Ongentys (opicapone) work?
Parkinson’s disease develops when neurons (brain cells) in a particular part of the brain stop working properly and are lost over time. These neurons produce an important chemical called dopamine. Dopamine is used by the brain to send messages across brain areas to help control movement. Eventually, the brain cannot make enough dopamine to control the movement properly. There is currently no cure for Parkinson’s Disease. Existing treatments aim to help patients manage symptoms3.
The active substance in Ongentys (opicapone) works to restore the levels of dopamine in the areas of the brain that control movement and coordination. It enhances the effects of another drug, levodopa, commonly used to treat Parkinson’s Disease. Opicapone blocks an enzyme that is involved in the breakdown of levodopa in the body, called catechol-O-methyl transferase (COMT). As a result, levodopa remains active for longer. This helps to relieve the symptoms of Parkinson’s disease, such as stiffness and slowness of movement1.
Is Ongentys (opicapone) approved?
Opicapone was approved for treating patients with Parkinson’s Disease as an add-on to levodopa/DOPA decarboxylase inhibitors (DDCI) in patients who are having fluctuations in the control of their condition1 by:
European Medicines Agency (EMA) June 24, 2016
How do I take Ongentys (opicapone)?
The recommended therapy consists of 50mg, taken once a day at bedtime, at least one hour before or after levodopa combination medicines1.
Note: Consult your treating doctor for personalised dosing.
Complete information on dosing can be found in the resources section.
The benefits of opicapone in Parkinson’s disease were investigated in two main studies. In the first study, 600 patients with fluctuations were given opicapone, entacapone (another medicine for Parkinson’s disease) or placebo (a dummy treatment), in addition to their current levodopa/DDCI combination. This study looked at how well the treatments reduced the ‘off periods' (the time when patients have more difficulty moving about). After 14–15 weeks, ‘off periods’ were shortened by 117 minutes (almost 2 hours) in patients taking opicapone 50mg, compared with 96 minutes in patients taking the comparator medicine entacapone and 56 minutes in patients taking placebo. In the second study, which also looked at the reduction in off periods, opicapone was compared with a placebo in 427 patients who were taking a levodopa / DDCI combination. After 14–15 weeks, ‘off periods’ were shortened by 119 minutes (almost 2 hours) in patients taking opicapone 50 mg, compared to 64 minutes in patients taking placebo. Both studies were extended for one additional year and confirmed the benefits of opicapone when used long-term1.
The most common side effects with opicapone are disorders of the nervous system (brain and spinal cord). Among these, dyskinesia (difficulty controlling movement) may affect around 2 in 10 people1.
During the transaction process I was very well informed by the TheSocialMedwork team. They have put as much of their effort to offer best service to me. Moreover the medicine I have ordered was imported two weeks earlier then it was expected. I highly recommend The Social Med Work.
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For prescription medicines you will always need a prescription from your treating doctor. This is to ensure that your treatment is monitored and led by a doctor who is responsible for administering the medicine to you. The prescription is the evidence that your doctor gives you their medical support.
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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.