Nuplazid (pimavanserin)

€5,539.55
In stock
SKU
Nuplazid (pimavanserin)

Nuplazid (pimavanserin) is a medication used for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. TheSocialMedwork processes this import on behalf of its pharmacy licensed partner NA Pharmacy Amsterdam (BIG registration No: 89912008117).

Neurology Parkinson's Disease
Marketing Authorisation Holder ACADIA Pharmaceuticals Inc
Mode of Action Atypical antipsychotic
Administration Oral
Regulatory agency approval Food and Drug Administration (FDA), USA
Strength 17 milligram
Package 60 Tablets

What is Nuplazid (pimavanserin) for?

Nuplazid (pimavanserin) is the first medicine approved for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis2.

How does Nuplazid (pimavanserin) work?

Hallucinations or delusions can occur in as many as 50% of patients with Parkinson’s disease at some time during the course of their illness. People who experience them see or hear things that are not there (hallucinations) and/or have false beliefs (delusions). Hallucinations and delusions experienced with Parkinson’s disease are serious symptoms which can lead to impaired thoughts and emotions that may be disturbing and disabling. As a result, patients may not relate to loved ones well or take appropriate care of themselves2. The mechanism of action of pimavanserin in the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis is unknown. However, its effect could be mediated through a combination of inverse agonist and antagonist activity at serotonin receptors1, which influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation3.

Is Nuplazid (pimavanserin) approved?

Nuplazid (pimavanserin) was approved for the treatment of patients with hallucinations and delusions associated with Parkinson’s disease psychosis2 by:

  • Food and Drugs Administration (FDA) (USA) on April 29, 2016

How do I take Nuplazid (pimavanserin)?

The standard dosage is:

  • 34 mg, taken orally as two 17 mg tablets once daily1
Complete information about Nuplazid (pimavanserin) dosage and administration can be found in the resources section.
Warning: Nuplazid (pimavanserin) is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis1.

Note: Consult your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Nuplazid (pimavanserin)?

Common adverse reactions

The most common adverse reactions (≥5% patients) listed in the prescribing information include: 

  • peripheral edema

  • confusional state

Serious side effects

The serious adverse reactions listed in the prescribing information include: 

  • QT interval prolongation (heart rhythm disorder)

Use in specific populations

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death1. No drug in this class is approved to treat patients with dementia-related psychosis2.

Use of Nuplazid (pimavanserin) is not recommended in patients with severe renal impairment and in patients with hepatic impairment1.

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.

More Information
Working ingredient pimavanserin
Shipping method Controlled room temperature (temperature controlled)
Package 60
Therapeutic Area Neurology
Neurology Parkinson's Disease
Indication Hallucinations and delusions associated with Parkinson’s disease psychosis
Administration Oral
Mode of Action Atypical antipsychotic
Regulatory agency approval Food and Drug Administration (FDA), USA
Marketing Authorisation Holder ACADIA Pharmaceuticals Inc

The approval was based on a 6-week clinical trial involving 199 participants. In this study, pimavanserin was shown to be superior to placebo in decreasing the frequency and/or severity of hallucinations and delusions without worsening the primary motor symptoms of Parkinson’s disease2.


As with other atypical antipsychotic drugs, there is an increased risk of death associated with the use of these drugs to treat older people with dementia-related psychosis. No drug in this class is approved to treat patients with dementia-related psychosis2.

1. Summary of Product Characteristics [FDA]: Nuplazid (pimavanserin) [PDF]
    Acadia Pharmaceuticals Inc., Mar. 2018

2. FDA approves first drug to treat hallucinations and delusions associated with Parkinson’s disease
    FDA, April 2016

3. 5-HT receptor
    Wikipedia, cited March 2017 

Shipping Type Cold Chain
Shipping method Controlled room temperature (temperature controlled)
Dynamic Weight No
This content has been reviewed by our medical doctor Jan de Witt.

How can we help you?

We're ready to answer any question!

Our Support team is available between
9:00–18:00 Central European Time, Monday to Friday.

 

Don't speak English? We also speak
Afrikaans, Armenian, Bosnian, Bulgarian, Dutch, German, Italian, Lithuanian, Mandarin, Portuguese, Russian, Serbian, Slovenian, Spanish and Turkish

 

Speak a different language?
Send us a message and we’ll do our best to translate.

 

Our guarantee: We will reply to all messages within 2 hours during office hours.

 

If you want to reach us via phone or chat, please visit our contact page

 

The Social Medwork is registered with the Dutch Ministry of Health in The Hague as an independent intermediary, Registration number 6730 BEM
100% legal and regulated
Registered with the Dutch Ministry of Health as an independent intermediary.

 

Registration number 6730 BEM
Secured logistics globally
• Standard and express delivery (DHL or UPS)
• 24/7 track & trace delivery
• Temperature regulated shipping
Secure payments
All payments are handled securely and are SSL encrypted.
We accept:
Bank transfer & Credit card

 

Patient reviews

 Tomasz Maćkowiak

During the transaction process I was very well informed by the TheSocialMedwork team. They have put as much of their effort to offer best service to me. Moreover the medicine I have ordered was imported two weeks earlier then it was expected. I highly recommend The Social Med Work.

Patient reviews

 Emina Mušović

Thank you for the wonderful cooperation! It's very reserved of us to say we're pleased because you really resolved all our doubts. The medicine has now arrived and we hope it helps. We know we were difficult, with the million different questions but well... That's all behind us now. Strongly recommended! :)

Patient reviews

 Mohamed Rahmat

I am fully satisfied with your online support service. Happy to deal with you.. fast & very fast support.. did not have to wait even 5 minutes! THANK YOU MEDWORK

Questions our patients are asking

visit our support page
You always need a prescription from a doctor based in your country. Other documents, such as an import license from the Ministry of Health, may be needed and depend on your country’s regulations. Contact us and we will provide you with all of the information about the required documents needed for your country.
For prescription medicines you will always need a prescription from your treating doctor. This is to ensure that your treatment is monitored and led by a doctor who is responsible for administering the medicine to you. The prescription is the evidence that your doctor gives you their medical support.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised medicine couriers. If you want us to use a specific courier please inform us when you place your order.
Yes. TheSocialMedwork is registered with the Dutch Ministry of Health as an independent medicines intermediary (registration number 6730 BEM). We always follow your country’s laws and regulations and will discuss any legal requirements with you. We only ship medicines when our patients have a prescription from their treating doctor.
By using TheSocialMedwork you will receive genuine medicines in perfect condition, no matter where you live.
Yes, you are welcome to visit us. We are located in the city centre of Amsterdam at the Herengracht 480. Contact us to schedule the best time for your visit.

 

You can order and receive your
medicine in 5 simple steps

1

Talk to your doctor

2

Place order
and send
prescription

3

Pay for order

4

Check documents
for delivery

5

Receive your medicine

Totally awesome!
Keep up the great
work you’re doing!


Dee Penfold - December 3, 2016
On TheSocialMedwork Facebook

Need a medicine that’s not
approved in your country?

We help patients, physicians and pharmacists acquire the latest life-changing medicines. Not available in your country? No problem - as long as it's approved by a reputable medical authority somewhere, we can help! Contact us today and our experienced team of qualified pharmacists and industry professionals will help you.


learn more
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.