Ongentys (opicapone)

In stock
Ongentys (opicapone)

How to buy Ongentys (opicapone): You can order Ongentys (opicapone) from TheSocialMedwork if the drug has not been approved or is not available in your country. We help patients and doctors get access to medicines at the lowest price worldwide.

Neurology Parkinson's Disease
Marketing Authorisation Holder Bial - Portela & Ca, S.A.
Mode of Action COMT inhibitor (dopamine enhancer)
Administration Oral
Regulatory agency approval European Medical Agency (EMA), European Union
Strength 50 milligram
Package 30 Capsules

What is Ongentys (opicapone) for?

Ongentys (opicapone) is indicated for the treatment of adult patients with Parkinson disease. It is used as an add-on to levodopa/DOPA decarboxylase inhibitors (DDCI) (other medicines for Parkinson’s disease) in patients who are having fluctuations in the control of their condition1

How does Ongentys (opicapone) work?

Parkinson’s disease develops when neurons (brain cells) in a particular part of the brain stop working properly and are lost over time. These neurons produce an important chemical called dopamine. Dopamine is used by the brain to send messages across brain areas to help control movement. Eventually, the brain cannot make enough dopamine to control the movement properly. There is currently no cure for Parkinson’s Disease. Existing treatments aim to help patients manage symptoms3.

The active substance in Ongentys (opicapone) works to restore the levels of dopamine in the areas of the brain that control movement and coordination. It enhances the effects of another drug, levodopa, commonly used to treat Parkinson’s Disease. Opicapone blocks an enzyme that is involved in the breakdown of levodopa in the body, called catechol-O-methyl transferase (COMT). As a result, levodopa remains active for longer. This helps to relieve the symptoms of Parkinson’s disease, such as stiffness and slowness of movement1.

Is Ongentys (opicapone) approved?

Opicapone was approved for treating patients with Parkinson’s Disease as an add-on to levodopa/DOPA decarboxylase inhibitors (DDCI) in patients who are having fluctuations in the control of their condition1 by:

  • European Medicines Agency (EMA) June 24, 2016 

How do I take Ongentys (opicapone)?

The recommended therapy consists of 50mg, taken once a day at bedtime, at least one hour before or after levodopa combination medicines1.

Note: Consult your treating doctor for personalised dosing.

Complete information on dosing can be found in the resources section.

More Information
Working ingredient opicapone
Shipping method Standard (not temperature controlled)
Package 30
Therapeutic Area Neurology
Neurology Parkinson's Disease
Indication Parkinson's disease
Administration Oral
Mode of Action COMT inhibitor (dopamine enhancer)
Regulatory agency approval European Medical Agency (EMA), European Union
Marketing Authorisation Holder Bial - Portela & Ca, S.A.
HS Code 30029090
CAS Number 923287-50-7

The benefits of opicapone in Parkinson’s disease were investigated in two main studies. In the first study, 600 patients with fluctuations were given opicapone, entacapone (another medicine for Parkinson’s disease) or placebo (a dummy treatment), in addition to their current levodopa/DDCI combination. This study looked at how well the treatments reduced the ‘off periods' (the time when patients have more difficulty moving about). After 14–15 weeks, ‘off periods’ were shortened by 117 minutes (almost 2 hours) in patients taking opicapone 50mg, compared with 96 minutes in patients taking the comparator medicine entacapone and 56 minutes in patients taking placebo. In the second study, which also looked at the reduction in off periods, opicapone was compared with a placebo in 427 patients who were taking a levodopa / DDCI combination. After 14–15 weeks, ‘off periods’ were shortened by 119 minutes (almost 2 hours) in patients taking opicapone 50 mg, compared to 64 minutes in patients taking placebo. Both studies were extended for one additional year and confirmed the benefits of opicapone when used long-term1.

The most common side effects with opicapone are disorders of the nervous system (brain and spinal cord). Among these, dyskinesia (difficulty controlling movement) may affect around 2 in 10 people1.

1. Human Medicines: Ongentys (opicapone)
    EMA, cited Nov 2016

2. Summary of Product Characteristics [EMA]: Ongentys (opicapone)
    Bial – Portela & Cª, Feb. 2017

3. Parkinson's UK
    cited nov 2016

Shipping Type Standard
Shipping method Standard (not temperature controlled)
This content has been reviewed by our medical doctor Jan de Witt.

How can we help you?

We're ready to answer any question!

Don't speak English? We also speak
Armenian, Bosnian, Bulgarian, Dutch, Filipino, German, Italian, Hebrew, Lithuanian, Portuguese, Russian, Serbian, Slovenian, Spanish, Swedish and Turkish.


Speak a different language?
Send us a message and we’ll do our best to translate.


Our guarantee: We will reply to all messages within 2 hours during office hours.


If you want to reach us via phone or chat, please visit our contact page


The Social Medwork is registered with the Dutch Ministry of Health in The Hague as an independent intermediary, Registration number 6730 BEM
100% legal and regulated
Registered with the Dutch Ministry of Health as an independent intermediary.


Registration number 6730 BEM
Secured logistics globally
• Standard and express delivery (DHL or UPS)
• 24/7 track & trace delivery
• Temperature regulated shipping
Secure payments
All payments are handled securely and are SSL encrypted.
We accept:
Bank transfer & Credit card


Patient reviews

 Tomasz Maćkowiak

During the transaction process I was very well informed by the TheSocialMedwork team. They have put as much of their effort to offer best service to me. Moreover the medicine I have ordered was imported two weeks earlier then it was expected. I highly recommend The Social Med Work.

Patient reviews

 Emina Mušović

Thank you for the wonderful cooperation! It's very reserved of us to say we're pleased because you really resolved all our doubts. The medicine has now arrived and we hope it helps. We know we were difficult, with the million different questions but well... That's all behind us now. Strongly recommended! :)

Patient reviews

 Mohamed Rahmat

I am fully satisfied with your online support service. Happy to deal with you.. fast & very fast support.. did not have to wait even 5 minutes! THANK YOU MEDWORK

Questions our patients are asking

visit our support page
You always need a prescription from a doctor based in your country. Other documents, such as an import license from the Ministry of Health, may be needed and depend on your country’s regulations. Contact us and we will provide you with all of the information about the required documents needed for your country.
For prescription medicines you will always need a prescription from your treating doctor. This is to ensure that your treatment is monitored and led by a doctor who is responsible for administering the medicine to you. The prescription is the evidence that your doctor gives you their medical support.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised medicine couriers. If you want us to use a specific courier please inform us when you place your order.
Yes. TheSocialMedwork is registered with the Dutch Ministry of Health as an independent medicines intermediary (registration number 6730 BEM). We always follow your country’s laws and regulations and will discuss any legal requirements with you. We only ship medicines when our patients have a prescription from their treating doctor.
By using TheSocialMedwork you will receive genuine medicines in perfect condition, no matter where you live.
Yes, you are welcome to visit us. We are located in the city centre of Amsterdam at the Herengracht 480. Contact us to schedule the best time for your visit.


You can order and receive your
medicine in 5 simple steps


Talk to your doctor


Place order
and send


Pay for order


Check documents
for delivery


Receive your medicine

Totally awesome!
Keep up the great
work you’re doing!

Dee Penfold - December 3, 2016
On TheSocialMedwork Facebook

Need a medicine that’s not
approved in your country?

We help patients, physicians and pharmacists acquire the latest life-changing medicines. Not available in your country? No problem - as long as it's approved by a reputable medical authority somewhere, we can help! Contact us today and our experienced team of qualified pharmacists and industry professionals will help you.

learn more
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.