Edaravone (generic)

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Edaravone (generic)

How to buy edaravone: You can order edaravone via TheSocialMedwork if the drug has not been approved and/or is not available in the patient's country. 

For this product the estimated delivery time is usually between 15 and 20 working days.

Neurology Cerebral Infarction
Marketing Authorisation Holder Pfizer Japan Inc.
Mode of Action Radical scavenger
Administration Intravenous
Regulatory agency approval Pharmaceuticals and Medical Devices Agency (PMDA), Japan

What is edaravone for?

Edaravone is a radical scavenger used to treat patients with acute cerebral infarction1,2. Edaravone is used also for the treatment of patients with ALS3,4.

How does edaravone work?

Free radicals such as hydroxyl radical (-OH) play a major causative role in the development of cerebral vascular disorder resulting from ischaemia. During ischaemia or ischaemic reperfusion, the production of free radicals increases which leads to cell membrane injury and ultimately to cerebral dysfunction. By eliminating free radicals, it is effective to suppress cell membrane lipid peroxidation1,2.

Where has edaravone been approved?

Edaravone was approved by the PMDA (JAP) for the treatment of acute cerebral infarction1,2.
The active ingredient edaravone is the main component of a drug produced by Mitsubishi Tanabe named Radicut in Japan and Radicava in USA. Under these names, edaravone is approved for the treatment of patients affected by ALS. The results of the clinical studies on patients affected by ALS can be found in our resources section6,7,8.

How is edaravone taken?

Complete information about edaravone dosage and administration for the treatment of cerebral infarction can be found in our resources section1,2.

  • 30 mg of edaravone administered intravenously over 30 minutes twice a day in the morning and the evening.
  • Administration of this product should be initiated within 24 hours after the onset of the disease, and the duration of administration should be within 14 days.
  • Consider terminating administration in a shorter period depending on symptoms.

Edaravone is the active ingredient of two other drugs, Radicut and Radicava, which are indicated for the treatment of ALS. The standard dosage of Radicut and Radicava for adult patients with ALS is3,4:

  • 60 mg of edaravone (2 vials/bags) administered intravenously over 60 minutes once a day.
  • First cycle: daily dosing for 14 days followed by a 14-day drug-free period (28 vials/bags).
  • Subsequent treatment cycles: daily dosing for 10 days out of 14-day periods, followed by 14-day drug-free periods (20 vials/bags).

Edaravone is supplied in two formats:

  • Single-dose infusion bags containing 30 mg / 100 mL clear, colorless, sterile solution. The infusion bags are ready for use. No dilution is required2.
  • Single-dose vials containing 30 mg / 20 mL clear, colorless, sterile solution. Before the infusion, it should be diluted with an appropriate volume of physiological saline1.

Warning: Administer carefully to patients with renal dysfunction and dehydration, infectious diseases, liver dysfunction, heart disease, advanced consciousness disorder and to elderly people1,2. 

Note: Please consult with your treating doctor for personalised dosing.

More Information
Working ingredient edaravone
Shipping method Controlled room temperature (temperature controlled)
Therapeutic Area Neurology
Neurology Cerebral Infarction
Indication Neurological symptoms, disability in daily living, and functional impairment accompanying the acute phase of cerebral infarction
Administration Intravenous
Mode of Action Radical scavenger
Regulatory agency approval Pharmaceuticals and Medical Devices Agency (PMDA), Japan
Marketing Authorisation Holder Pfizer Japan Inc.
Shipping Type Standard
Shipping method Controlled room temperature (temperature controlled)
This content has been reviewed by our medical doctor Jan de Witt.

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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.