Descovy (emtricitabine/tenofovir alafenamide)

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Descovy (emtricitabine/tenofovir alafenamide)

You can order Descovy (emtricitabine/tenofovir alafenamide) from TheSocialMedwork if the drug has not been approved or is not available in your country. We help patients and doctors get access to medicines at the lowest price worldwide.

Infectiology HIV/AIDS
Marketing Authorisation Holder Gilead Sciences International Limited
Mode of Action Antiviral
Administration Oral
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia
Package 30 Tablets

What is Descovy (emtricitabine/tenofovir alafenamide) for?

Descovy (emtricitabine/tenofovir alafenamide) is indicated for the treatment of individuals infected with human immunodeficiency virus type 1 (HIV-1), a virus that causes acquired immunodeficiency syndrome (AIDS). It is used in adults and adolescents aged over 12 years and who weigh at least 35 kg1.

How does Descovy (emtricitabine/tenofovir alafenamide) work?

Each tablet of Descovy (emtricitabine/tenofovir alafenamide) contains 200 mg of emtricitabine and either 10 or 25 mg of tenofovir alafenamide. Inside the body tenofovir alafenamide is converted into the active substance tenofovir. Tenofovir and emtricitabine block the activity of the enzyme made by the virus to reproduce itself in the cells it has infected. It thus keeps the amount of HIV in the blood at a low level.

Descovy (emtricitabine/tenofovir alafenamide) does not cure HIV infection or AIDS, but it can prevent damages to the immune system and the development of infections and diseases associated with AIDS.

Is Descovy (emtricitabine/tenofovir alafenamide) approved?

Descovy (emtricitabine/tenofovir alafenamide) was approved For the treatment of HIV-1 infection* by:

  • FDA on April 4, 20165

  • EMA (EU) on April 21, 20161

  • TGA (AUS) on November 22, 20164

*in adults and pediatric patients 12 years of age and older in combination with other antiretroviral agents.  

How do I take Descovy (emtricitabine/tenofovir alafenamide)?

The FDA standard dosage is:

  • 1 tablet 200 mg / 25 mg daily

The EMA and TGA standard dosage is:

  • 200 mg / 10 mg once daily if taken together with atazanavir with ritonavir or cobicistat, darunavir with ritonavir or cobicistat, or lopinavir with ritonavir

  • 200 mg / 25 mg once daily if taken with dolutegravir, efavirenz, maraviroc, nevirapine, rilpivirine, or raltegravir2,4

Complete information about Descovy (emtricitabine / tenofovir alafenamide) dosage and administration can be found in the resources section2,3,4.

Note: Consult your treating doctor for personalised dosing.

Known side effects of Descovy (emtricitabine/tenofovir alafenamide)

The most common side effect is nausea (feeling sick). Other common side effects include diarrhoea and headache1

More Information
Working ingredient emtricitabine/tenofovir alafenamide
Shipping method Standard (not temperature controlled)
Package 30
Therapeutic Area Infectious diseases
Infectiology HIV/AIDS
Indication HIV-1 infection treatment
Administration Oral
Mode of Action Antiviral
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia
Marketing Authorisation Holder Gilead Sciences International Limited

The approvals were based on several studies that compared emtricitabine /tenofovir alafenamide (F/TAF)-based regimens (i.e. regimens including Descovy) with emtricitabine / tenofovir disoproxil (F/TDF)-based regimens (e.g. regimens including Viread), and demonstrated the ability of Descovy (F/TAF) to produce the same drug levels as F/TDF regimens at a dose of tenofovir of less than one tenth5,2.

Clinical studies on treatment-naive patients (GS-US-292-0104 and GS-US-292-0111) have shown that F/TAF-based regimens produce similar results, in terms of viral load, to F/TDF-based regimens. The number of individuals with a viral load (HIV-1 RNA) of less than 50 copies per mL of plasma after 48 weeks was 92% for those on F/TAF and 90% for those on F/TDF, while being 84% vs 80% after 144 weeks2.

In study GS-US-311-1089, the efficacy and safety of switching from F/TDF to Descovy (F/TAF) while maintaining the third antiretroviral agent were evaluated in patients with a stable low viral load for at least 6 months (HIV-1 RNA < 50 copies/mL). The percentage of individuals with a maintained low viral load was similar in the tested cohorts and in both around 90%2.

Moreover, F/TAF-based regimens were associated with smaller reductions in bones mineral density (BMD) and a lower impact on renal safety parameters as compared to F/FDF-based regimens2.

Shipping Type Standard
Shipping method Standard (not temperature controlled)
This content has been reviewed by our medical doctor Jan de Witt.

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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.