Lonsurf (trifluridine/tipiracil)

In stock
Lonsurf (trifluridine/tipiracil)

Lonsurf (trifluridine / tipiracil) is a medication used for the treatment of advanced (metastatic) colorectal cancer.

Oncology Colorectal Cancer
Marketing Authorisation Holder Les Laboratoires Servier
Mode of Action Cytotoxic agent (chemotherapy)
Administration Oral
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia

What is Lonsurf (trifluridine/tipiracil) for?

Lonsurf (trifluridine/tipiracil) is a chemotherapy indicated for the treatment of people with advanced (metastatic) colorectal cancer who have been previously treated with chemotherapy and biological therapy1,2.

How does Lonsurf (trifluridine/tipiracil) work?

Lonsurf (trifluridine/tipiracil) is a cytotoxic medicine (a medicine that kills cells that are dividing, such as cancer cells). It contains two active substances: trifluridine and tipiracil. In the body, trifluridine is converted into an active form that is incorporated directly into DNA, the genetic material of cells. As a result, trifluridine interferes with DNA function and prevents the cells from dividing and multiplying. The conversion of trifluridine into its active form occurs more readily in cancer cells than in normal cells, leading to higher levels of the active form of the medicine and a longer duration of action in cancer cells. This results in a reduced growth of cancer cells, while normal cells are only slightly affected. Tipiracil increases the level of trifluridine in the blood by slowing its breakdown. This, therefore, boosts trifluridine’s effect2.

Where has Lonsurf (trifluridine/tipiracil) been approved?

Lonsurf (trifluridine/tipiracil) was approved for previously treated advanced (metastatic) colorectal cancer by:

  • Food and Drug Administration (FDA), USA, September 22, 2015

  • European Medical Agency (EMA), European Union, April 25, 2016

  • Therapeutic Goods Administration (TGA), Australia, May 23, 2017

Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

How is Lonsurf (trifluridine/tipiracil) taken?

The standard dosage is3,4,6:

  • 35 mg/m2/dose orally twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.

Take trifluridine/tipiracil within 1 hour after completion of morning and evening meals.

Complete information about Lonsurf (trifluridine/tipiracil) dosage and administration can be found in the official prescribing information listed in our resources section3,4,6.

It is recommended that healthcare providers obtain complete blood counts prior to starting each treatment cycle of Lonsurf and monitor patients throughout treatment, as trifluridine/tipiracil may cause a severe decrease in blood cell and platelet production (myelosuppression)1,4.

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Lonsurf (trifluridine/ tipiracil)?

Common adverse reactions

The most common adverse reactions listed in the prescribing information include3,4,6:

  • Abnormal blood counts (anemia, neutropenia, thrombocytopenia)

  • asthenia/fatigue (lack of energy, tiredness)

  • nausea

  • decreased appetite

  • diarrhea

  • vomiting

  • pyrexia (fever)

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include3,4,6:

  • bone marrow suppression (myelosuppression including anaemia, neutropenia,
    leucopenia, and thrombocytopenia)

  • gastrointestinal toxicity (severe or persistent nausea, vomiting, diarrhoea, or abdominal pain)

Use in specific populations

As Lonsurf (trifluridine / tipiracil) can be fatal for a fetus, it is not advised for women who are pregnant or breast-feeding.

Avoid use in patients with moderate to severe hepatic impairment (liver dysfunction), and in patients with moderate renal impairment (kidney dysfunction)3,4,6.

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information3,4,6.

More Information
Working ingredient trifluridine/tipiracil
Shipping method Controlled room temperature (temperature controlled)
Therapeutic Area Oncology
Oncology Colorectal Cancer
Indication Metastatic colorectal cancer
Administration Oral
Mode of Action Cytotoxic agent (chemotherapy)
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia
Marketing Authorisation Holder Les Laboratoires Servier
HS Code 29335995
CAS Number 183204-74-2

Clinical trials – Lonsurf (trifluridine / tipiracil)

Approvals by the Food and Drug Administration (FDA), USA, European Medical Agency (EMA), European Union, Therapeutic Goods Administration (TGA), Australia, of Lonsurf (trifluridine / tipiracil) for metastatic colorectal cancer in previously treated patients were based on one randomised, double-blind phase III study (RECOURSE). This study involved a total of 800 patients with previously treated metastatic colorectal cancer. Patients received either Lonsurf plus best supportive care or placebo plus best supportive care. Patients continued therapy until disease progression or unacceptable toxicity3,4,6.


Among the major efficacy outcome measures were overall survival (OS) and progression-free survival (PFS).

The median OS was3,4,6:

  • 7.1 months [95% CI: 6.5, 7.8] with Lonsurf (trifluridine/tipiracil)

    • Rate of deaths: 68.2%

  • 5.3 months [95% CI: 4.6, 6.0] with placebo

    • Rate of deaths: 78.9%

The median PFS was3,4,6:

  • 2.0 months [95% CI: 1.9, 2.1] with Lonsurf (trifluridine/tipiracil)

    • Rate of progressions or deaths: 88.4%

  • 1.7 months [95% CI: 1.7, 1.8] with placebo

    • Rate of progressions or deaths: 94.4%

Shipping Type Standard
Shipping method Controlled room temperature (temperature controlled)
This content has been reviewed by our medical doctor Jan de Witt.

How can we help you?

We're ready to answer any question!

Don't speak English? We also speak
Afrikaans, Armenian, Bosnian, Bulgarian, Dutch, German, Italian, Lithuanian, Mandarin, Portuguese, Russian, Serbian, Slovenian, Spanish and Turkish


Speak a different language?
Send us a message and we’ll do our best to translate.


Our guarantee: We will reply to all messages within 2 hours during office hours.


If you want to reach us via phone or chat, please visit our contact page


The Social Medwork is registered with the Dutch Ministry of Health in The Hague as an independent intermediary, Registration number 6730 BEM
100% legal and regulated
Registered with the Dutch Ministry of Health as an independent intermediary.


Registration number 6730 BEM
Secured logistics globally
• Standard and express delivery (DHL or UPS)
• 24/7 track & trace delivery
• Temperature regulated shipping
Secure payments
All payments are handled securely and are SSL encrypted.
We accept:
Bank transfer & Credit card


Patient reviews

 Tomasz Maćkowiak

During the transaction process I was very well informed by the TheSocialMedwork team. They have put as much of their effort to offer best service to me. Moreover the medicine I have ordered was imported two weeks earlier then it was expected. I highly recommend The Social Med Work.

Patient reviews

 Emina Mušović

Thank you for the wonderful cooperation! It's very reserved of us to say we're pleased because you really resolved all our doubts. The medicine has now arrived and we hope it helps. We know we were difficult, with the million different questions but well... That's all behind us now. Strongly recommended! :)

Patient reviews

 Mohamed Rahmat

I am fully satisfied with your online support service. Happy to deal with you.. fast & very fast support.. did not have to wait even 5 minutes! THANK YOU MEDWORK

Questions our patients are asking

visit our support page
You always need a prescription from a doctor based in your country. Other documents, such as an import license from the Ministry of Health, may be needed and depend on your country’s regulations. Contact us and we will provide you with all of the information about the required documents needed for your country.
For prescription medicines you will always need a prescription from your treating doctor. This is to ensure that your treatment is monitored and led by a doctor who is responsible for administering the medicine to you. The prescription is the evidence that your doctor gives you their medical support.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised medicine couriers. If you want us to use a specific courier please inform us when you place your order.
Yes. TheSocialMedwork is registered with the Dutch Ministry of Health as an independent medicines intermediary (registration number 6730 BEM). We always follow your country’s laws and regulations and will discuss any legal requirements with you. We only ship medicines when our patients have a prescription from their treating doctor.
By using TheSocialMedwork you will receive genuine medicines in perfect condition, no matter where you live.
Yes, you are welcome to visit us. We are located in the city centre of Amsterdam at the Herengracht 480. Contact us to schedule the best time for your visit.


You can order and receive your
medicine in 5 simple steps


Talk to your doctor


Place order
and send


Pay for order


Check documents
for delivery


Receive your medicine

Totally awesome!
Keep up the great
work you’re doing!

Dee Penfold - December 3, 2016
On TheSocialMedwork Facebook

Need a medicine that’s not
approved in your country?

We help patients, physicians and pharmacists acquire the latest life-changing medicines. Not available in your country? No problem - as long as it's approved by a reputable medical authority somewhere, we can help! Contact us today and our experienced team of qualified pharmacists and industry professionals will help you.

learn more
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.