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How to buy Cabometyx (cabozantinib): You can order Cabometyx (cabozantinib) from TheSocialMedwork if the drug has not been approved or is not available in your country. We help patients and doctors get access to medicines at the lowest price worldwide.
Marketing Authorisation Holder
Mode of Action
Tyrosine kinase inhibitor
Regulatory agency approval
European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA, Therapeutic Goods Administration (TGA), Australia
Cabometyx (cabozantinib) is indicated for the treatment of patients with advanced renal cell carcinoma (a type of kidney cancer) who have received prior anti-angiogenic therapy1,2 (therapy that inhibits the formation of new blood vessels that supply the tumour with oxygen and nutrients5). In December 2017 the FDA extended the approval to previously untreated patients with advanced renal cell carcinoma (RCC)6.
How does Cabometyx (cabozantinib) work?
The active substance in Cabometyx, cabozantinib, is a ‘tyrosine kinase inhibitor’. This means that it blocks the activity of enzymes known as tyrosine kinases. These enzymes can be found in cancer cells, where they activate several processes including cell division and the growth of new blood vessels to supply the cancer. By blocking the activity of these enzymes in cancer cells, Cabometyx (cabozantinib) reduces the growth and spread of the cancer3.
Is Cabometyx (cabozantinib) been approved?
Cabometyx (cabozantinib) was approved for advanced renal cell carcinoma previously treated with an anti-angiogenic therapy by:
Food and Drug Administration (FDA), USA:
April 25, 20164 as second line treatment
December 19, 20176 as first line treatment
European Medical Agency (EMA), European Union, September 9, 20163
Therapeutic Goods Administration (TGA), Australia, January 19, 20187.
How is Cabometyx (cabozantinib) taken?
The standard dosage is:
60 mg orally, once daily
Patients should not eat for at least 2 hours before and at least 1 hour after assumption
Cabozantinib tablets should not be substituted with cabozantinib capsules.
Complete information about Cabometyx (cabozantinib) dosage and administration can be found in the resources section.
Note: Consult your treating doctor for personalised dosing.
Are there any known adverse reactions or side effects of Cabometyx (cabozantinib)?
Common adverse reactions
The most common adverse reactions (≥ 25% of patients) listed in the prescribing information include1,2,7:
palmar-plantar erythrodysesthesia (PPE)
Serious side effects
The serious adverse reactions listed in the prescribing information include:
Cabometyx (cabozantinib) can be fatal for a fetus, it is advised to avoid pregnancies and breastfeeding. The dose should be reduced in patients with mild or moderate hepatic impairment. Cabometyx (cabozantinib) is not recommended for use in patients with severe hepatic impairment1,2.
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information1,2,7.
Approvals for Cabometyx (cabozantinib) were based on a study involving 658 adults with advanced renal cell carcinoma that had got worse despite treatment with an anti-angiogenic therapy. In the study, Cabometyx (cabozantinib) was compared with the cancer medicine everolimus1,2.
Results showed a progression-free survival (time patients lived without their disease getting worse) of 7.4 months on average (95% CI: 6.6, 9.1) compared with 3.8 months (95% CI: 3.7, 5.1) in patients treated with everolimus1. The overall response rate (ORR) was 24% (95% CI: 19, 29) with cabozantinib and 4% (95% CI: 2, 7)1. Preliminary results indicated that patients treated with Cabometyx (cabozantinib) lived overall longer than patients treated with everolimus (an average of 21.4 months compared with 16.5 months)3.
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For prescription medicines you will always need a prescription from your treating doctor. This is to ensure that your treatment is monitored and led by a doctor who is responsible for administering the medicine to you. The prescription is the evidence that your doctor gives you their medical support.
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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.