Xermelo (telotristat ethyl)

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Xermelo (telotristat ethyl)

This product, although approved, is not yet available to purchase via TheSocialMedwork. However, if you are interested in staying informed please leave your email address, and we will update you as soon as we are able to source it and offer it for purchase.

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Manufacturer Lexicon Pharmaceuticals
Disease Carcinoid syndrome
Indication Carcinoid syndrome diarrhea
Approval Status EMA approved (EU); FDA approved (USA)

Other medicines for carcinoid syndrome

If you are interested in other medicines for carcinoid syndrome, please visit our carcinoid syndrome.

What is telotristat ethyl?

Xermelo (telotristat ethyl) is a tryptophan hydroxylase inhibitor indicated for adults with severe diarrhoea associated with a condition called carcinoid syndrome [1][2]. Carcinoid syndrome is a set of symptoms sometimes seen in people with carcinoid tumours, whose tumours release excess amounts of the hormone serotonin, resulting in diarrhea, flushing of the face and cramps [3][4]

Xermelo is used together with other medicines, called somatostatin analogues, when those medicines are not sufficient on their own to control the diarrhoea [3]. Telotristat inhibits enzymes needed for the production of serotonin and by reducing the production of serotonin it relieves the symptoms of the condition [3].

When will telotristat ethyl be available?

Xermelo (telotristat ethyl) was approved by the FDA on February 28, 2017 [4] and by the EMA on  September 18, 2017 [3]. We have already contacted our sourcing partners and we will offer this product on our website as soon as we are able to source it for our patients.

[1] Summary of Product Characteristics [FDA]: Xermelo (telotristat ethyl), Lexicon Pharmaceuticals, Feb. 2017.
[2] Summary of Product Characteristics [EMA]: Xermelo (telotristat ethyl), Ipsen Pharma, Oct. 2017.
[3] EMA: Xermelo (telotristat ethyl). 20/10/2017, cited on 20/12/2107.
[4] FDA News Release: FDA approves Xermelo for carcinoid syndrome diarrhea, 28/02/2017.

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.

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