|| Eli Lilly and Co.
|| Plaque psoriasis
| Mode of Action
|| Humanised interleukin-17A antagonist
| Approval Status
|| EMA approved (EU); FDA approved (USA); TGA approved (AUS)
|| 80 mg/mL
Who is ixekizumab for?
Taltz (ixekizumab) is indicated for the treatment of patients with moderate to severe plaque psoriasis  who are candidates for systemic therapy or phototherapy .
Complete information about Taltz (ixekizumab) dosage and administration can be found here: .The standard dosage is:
- first dose of 160 mg (two injections)
- for the first 12 weeks: an injection of 80 mg every 2 weeks
- thereafter an injection of 80 mg every 4 weeks.
Instruction for the use of the prefilled syringe can be found here 
, whilst instructions for the use of the prefilled pen can be found here 
.Consult your treating doctor for personalised dosing.
What is ixekizumab and how does it work?
Taltz (ixekizumab) is a monoclonal antibody used to treat adults with moderate to severe plaque psoriasis . The active ingredient in Taltz, ixekizumab, is a humanised interleukin-17A antagonist ; a protein designed to attach to interleukin 17A, a messenger molecule in the immune system. Interleukin 17A is involved in immune system effects, including inflammation, that cause psoriasis. By attaching to interleukin 17A, ixekizumab blocks its action and reduces the activity of the immune system, thereby reducing the symptoms of psoriasis .
What is ixekizumab's approval status?
Ixekizumab was approved by:
for the treatment of adults with moderate to severe plaque psoriasis.The approvals were based on 3 main clinical trials (UNCOVER-1,2,3) involving 3,866 patients with psoriasis . All 3 studies compared ixekizumab administered at a dosage of 80 mg (after an initial injection of 160 mg) every 2 (N = 1169) or every 4 weeks (N= 1165), with placebo (N= 792). Two trials compared ixekizumab also to etanercept (N = 740). The parameters used for the comparison were the static Physician Global Assessment (sPGA) and the Psoriasis Area and Severity Index (PASI) . The sPGA is a measure of the status of the psoriatic lesions of a patient (i.e., plaque thickness/induration, erythema, scaling) on a severity scale from 0 (=clear) to 5 (=severe) . The PASI additionally to the severity of the lesions takes into account the body surface area covered with psoriatic lesions . The results presented here are the average across the 3 studies, the complete results can be found here: .After 12 weeks ixekizumab administered every 2 weeks resulted as superior in all the measured parameters to all other tested conditions. The sPGA was equal to 0 (=clear) or 1 (=almost clear) in 81.8 % of the patients treated with ixekizumab every 2 weeks and almost 40 % of these had clear skin (sPGA =1 in 39.7 % of the patients and 37.8 % had a reduction of 100 % in PASI). On the other hand the sPGA was equal to 0 or 1 in 74.9 % of the patients treated with ixekizumab every 4 weeks, 38.8 % of those treated with etanercept and 4.1 % in the placebo cohort . Almost 89 % of those treated every two weeks with ixekizumab attained a 75 % reduction in the PASI after 12 weeks, which compares with 82.5 % of the patients on ixekizumab every 4 weeks, 47.5 % of patients on etanercept, and 4.5 % of those given placebo .To evaluate the maintenance and durability of the response, two studies continued for an additional 48 weeks in patients who at week 12 had responded to ixekizumab (both those on the biweekly plan and those on the monthly plan). These patients were randomly assigned to a maintenance dosage of ixekizumab every 4 weeks or to placebo. The best results were obtained in patients who took ixekizumab every 2 weeks for the first 12 weeks and every 4 weeks for the following 48 weeks. In this cohort, 78.3 % of the patients maintained a sPGA of 0 or 1, and about 58 % of these had maintained or achieved clear skin (sPGA = 0 in 58.8 % and 100 % reduction in PASI in 57.5 %). On the other hand, only about 7 % of the initial responders that switched to placebo had a sPGA of 0 or 1 , meaning that most of them relapsed after interruption of the treatment with ixekizumab.
- FDA (USA) on March 22, 2016 
- EMA (EU) on May 2, 2016 
- TGA (AUS) on September 6, 2016 
The most common side effects are pain and redness at the injection site, and nose, throat or chest infections. It must not be given to patients who have potentially serious infections such as tuberculosis 
EMA. Human Medicines: Taltx (ixekizumab), 02/05/2016 (last update: 15/12/2016), cited on 16/03/2017. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003943/human_med_001977.jsp&mid=WC0b01ac058001d124
Summary of Product Characteristics [FDA]: Taltz (ixekizumab), Eli Lilly and Co., Mar. 2016. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/125521s000lbl.pdf
Summary of Product Characteristics [TGA]: Taltz (ixekizumab), Eli Lilly Australia Pty. Ltd., Apr. 2017. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2016-PI-02453-1&d=2017031316114622483
Summary of Product Characteristics [EMA]: Taltz (ixekizumab), Eli Lilly Nederland B.V., Dec. 2016. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003943/WC500205804.pdf
Instructions for use: Taltz (ixekizumab) prefilled syringe. Mar. 2016. http://pi.lilly.com/us/taltz-pfs-us-ifu.pdf
Instructions for use: Taltz (ixekizumab) prefilled pen https://www.medicines.org.uk/emc/PIL.32045.latest.pdf
Chow C., et al. Comparison of three methods for measuring psoriasis severity in clinical studies (Part 1 of 2): change during therapy in Psoriasis Area and Severity Index, Static Physician's Global Assessment and Lattice System Physician's Global Assessment. J Eur Acad Dermatol Venereol. 2015 Jul.; 29 (7):1406–1414. http://onlinelibrary.wiley.com/wol1/doi/10.1111/jdv.13132/full
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Medicine information contained herein may be time sensitive. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Always consult your treating physician before starting a course of treatment.