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Onivyde (liposomal irinotecan)
How to buy Onivyde:
You can order Onivyde (irinotecan liposome) via TheSocialMedwork if the drug has not been approved and/or is not available in the patient's country. TheSocialMedwork - helping patients and doctors access the latest approved medicines and at the lowest price possible worldwide.
Baxalta Innovations GmbH
Mode of Action
EMA approved (EU); FDA approved (USA)
Who is liposomal irinotecan injection for?
Onivyde (liposomal irinotecan) is indicated in combination with 5-fluorouracil and leucovorin (two other cancer medicines ) for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy .
Complete information about Onivyde (liposomal irinotecan) dosage and administration can be found here . Note that 1 mL of the EMA approved Onivyde marketed by Baxalta Innovations GmbH contains the equivalent of 5 mg irinotecan hydrochloride trihydrate (as irinotecan sucrosofate salt in a pegylated liposomal formulation) which corresponds to 4.3 mg/1 mLirinotecan . The latter is the strength approved by the FDA and marketed by Merrimack Pharmaceuticals Inc. . The standard EMA dosage is:
80 mg/m2 administered by intravenous infusion every 2 weeks followed by 5‑fluorouracil and leucovorin.
The standard FDA dosage is:
70 mg/m2 administered by intravenous infusion every 2 weeks followed by 5‑fluorouracil and leucovorin .
What is liposomal irinotecan and how does it work?
Onivyde (liposomal irinotecan) is a cancer medicine used to treat adults with metastatic adenocarcinoma of the pancreas. It is used together with 5-fluorouracil and leucovorin (two other cancer medicines) in adults whose cancer has worsened despite treatment containing the cancer medicine gemcitabine .The active substance in Onivyde, irinotecan, is a topoisomerase inhibitor. It blocks an enzyme called topoisomerase I. This enzyme is involved in copying cell DNA, which is needed to make new cells. By blocking the enzyme, cancer cells are prevented from multiplying and they eventually die. In Onivyde, irinotecan is contained within tiny fat particles called ‘liposomes’. The liposomes are expected to accumulate within the tumour and release the medicine slowly over time, thereby allowing it to act for longer .
for metastatic adenocarcinoma of the pancreas for use in combination with 5-fluorouracil and leucovorin in adults whose cancer has gotten worse despite treatment containing the cancer medicine gemcitabine. The approvals were based on a study involving 417 adults with metastatic adenocarcinoma of the pancreas whose cancer worsened despite cancer treatment that contained gemcitabine. Patients were given Onivyde or 5-fluorouracil plus leucovorin, or the three medicines in combination. The main measure of effectiveness was that the addition of Onivyde to the 5-fluorouracil plus leucovorin regimen prolonged patients’ lives. Patients taking the three medicines together lived for around 6.1 months, compared with 4.2 months for patients taking 5-fluorouracil plus leucovorin, and 4.9 months for patients taking Onivyde alone .
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