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How to buy Odomzo:
You can order Odomzo (sonidegib) via TheSocialMedwork if the drug has not been approved and/or is not available in the patient's country. TheSocialMedwork - helping patients and doctors access the latest approved medicines and at the lowest price possible worldwide.
Eli Lilly and Co.
Locally advanced basal cell carcinoma
Mode of Action
Hedgehog pathway inhibitor
EMA approved (EU); FDA approved (USA); TGA approved (AUS)
Who is sonidegib for?
Odomzo (sonidegib) is indicated for the treatment of patients with basal cell carcinoma which is locally advanced and which cannot be treated either by surgery or by radiotherapy .
Complete information about Odomzo (sonidegib) dosage and administration can be found here: . The standard dosage is:
One 200 mg capsule once a day at least 1 hour before and 2 hours after a meal.
Consult your treating doctor for personalised dosing.
What is sonidegib and how does it work?
Odomzo is a Hedgehog pathway inhibitor used to treat adults with locally advanced basal cell carcinoma (BCC) that has recurred following surgery or radiation therapy, or those who are not candidates for surgery or radiation therapy . The Hedgehog signaling pathway is a set of processes that control a number of cell activities including cell growth and correct development and differentiation. The active ingredient in Odomzo, sonidegib, attaches to a protein that controls the Hedgehog signaling pathway. By attaching to this protein, sonidegib blocks the Hedgehog signaling pathway and thereby reduces the growth and spread of cancer cells .
for the treatment of adults with locally advanced basal cell carcinoma (BCC) that cannot be treated with surgery or radiation therapy. The approvals of Odomzo (sonidegib) for locally advanced BCC were based on one main study involving 230 patients with basal cell carcinoma which was either locally advanced or metastatic. Patients were started on two different doses of sonidegib: 200 or 800 mg once a day. The response on metastatic BCC was less than 20 %. However, the medicine resulted effective on patients with locally advanced BCC with a response rate of 56 % (95 % CI: 43.3, 68.3) on the 200 mg dose, with 5 % complete responses, and 45 % (95 % CI: 43.3, 68.3)  on the 800 mg dose . On the 200 mg dosage, the time to tumour response was 4.0 months (95 % CI: 3.8, 5.6) and the median duration of response was 26.1 months .
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