| Manufacturer || Sanofi
| Disease || Several conditions involving inflammation in the body
| Indication || Asthma; Arthritis; Allergies; Tumours; Immune system suppression; Skin, kidney, heart, digestive system, eyes or blood conditions; Duchenne muscular dystrophy (off-label)
| Mode of Action || Glucocorticoid
| Approval Status || MHRA approved (UK); BfArM approved (DE)
| CAS Number || 853426-35-4
| HS Code || 30021098
| Strength || 6 mg
Who is deflazacort for?
Calcort (deflazacort) is indicated for the treatment of patients with several conditions. Among these are:
- inflammation including asthma, arthritis, and allergies
- skin, kidney, heart, digestive system, eyes or blood conditions
Calcort (deflazacort) can also be used to suppress the immune system in transplant operations.
Moreover, deflazacort has been frequently used for the treatment of Duchenne muscular dystrophy (DMD) 
and is referred to as the most commonly prescribed corticosteroid for DMD in Canada 
Complete information about Calcort (deflazacort). dosage and administration can be found here .Consult your treating doctor for personalised dosing.
What is deflazacort and how does it work?
Calcort (deflazacort) is a glucocorticoid used to treat several conditions involving inflammation of the body .
Glucocorticoids are a class of corticosteroids which occur naturally in the body and help to maintain health and wellbeing. Boosting your body with extra corticosteroid is an effective way to treat various illnesses involving inflammation of the body. Deflazacort works by reducing this inflammation. It also stops reactions known as autoimmune reactions. These reactions occur when your immune system attacks the body itself causing damage .
What is deflazacort’s approval status?
Unlike most of our products, deflazacort isn’t a new medicine and is marketed under several different names across the world . Among several other countries, it is approved under the name Calcort in the UK  and Germany . Besides its many uses in the treatment of inflammations and autoimmune diseases , the benefits of deflazacort on DMD emerged from several studies . Corticosteroids are the standard therapy to delay DMD progression  with some reports indicating less weight gain in patients using deflazacort than those using other corticosteroids, like prednisolone .In February 2017 deflazacort received FDA approval for the treatment of DMD under the name Emflaza, manufactured by Marathon Pharmaceuticals . This approval was based on a study of 196 boys, ranging from 5 to 15 years old . The study lasted 52 weeks and compared deflazacort at two different dosages (0.9 or 1.2 mg/ kg/ day) with prednisone (another corticosteroid commonly used to treat DMD) and placebo.
After 12 weeks of treatment, both deflazacort (at both dosages) and prednisone showed superior changes in average muscles strength scores: deflazacort produced a score of 0.15 with the dosage of 0.9 mg/ kg/ d (95 % CI 0.01—0.28) 
and a score of 0.26 with the of dosage 1.2 mg/ kg/ d (95 % CI 0.12—0.40); prednisone produced a score of 0.27 (95 % CI 0.13—0.41); placebo produced a score of -0.1 (95 % CI -0.23—0.03) 
. Moreover, both medications were better than placebo on several timed motor function tests (i.e., time to stand from supine, time to climb four stairs and time to walk or run 30 feet) 
.From week 12 to week 52 the group treated with deflazacort with the dosage of 0.9 mg/ kg/ d showed better results in changes of average muscle strength score (0.17, 95 % CI 0.03—0.31) than the group treated with prednisone (-0.12, 95 % CI -0.26—0.03) 
L.C. Mc Adam, et al. The Canadian experience with long term deflazacort treatment in Duchenne muscular dystrophy. Acta Myol. 2012 May; 31(1):16–20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440807/
Package leaflet: Calcort (deflazacort), Sanofi S.p.a., 20/12/2016. https://www.medicines.org.uk/emc/PIL.21423.latest.pdf
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FDA News Release: FDA approves drug to treat Duchenne muscular dystrophy, 09/02/2017. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm540945.htm
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B.L. Wong, et al. Long-term outcome of interdisciplinary management of patients with Duchenne muscular dystrophy receiving daily glucocorticoid treatment. J. of Pediatrics. 2017 Mar; 182:296–303. https://www.ncbi.nlm.nih.gov/pubmed/28043681
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K. Bushby, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. The Lancet Neurology. 2009 Nov; 9(1):77–93. http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(09)70271-6/fulltext
Marathon Pharmaceuticals News Release: FDA approves Emflaza (deflazacort) tablets and oral suspension for the treatment of Duchenne muscular dystrophy in patients 5 years and older, 09/02/2017. http://marathonpharma.com/news/2017/02/emflaza-deflazacort-just-fda-approved/
R.C. Griggs, et al. Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy. Neurology. 2016 Nov; 87(20):2123–2131. http://www.neurology.org/content/87/20/2123.long
Summary of Product Characteristics [FDA]: Emflaza (deflazacort), Marathon Pharmaceuticals LLC, Feb 2017. http://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208684s000,208685s000lbl.pdf